If a moleskine is the analog equivalent of a PDA, this is the Desktop: the Giant Sketch is a 8000 page, 18" tall notebook, available from MATTER. (via JoshSpear)
TokyoPlastic's Drum Machine is a brilliant piece of flash animation [Editor's Note: it's an oldie, but a classic, for anyone unfamiliar, check out their newer pieces as well!]
Lock Cup is meant to keep your bad roommate from using your cup, and is probably as useful as sticking your toothpaste in a little plastic bag before taking a plane.